UJI EFEK PENYEMBUHAN LUKA SEDIAAN GEL EKSTRAK ETANOL DAUN AFRIKA (VERNONIA AMYGDALINA.DEL) PADA MENCIT JANTAN

Abstract

African leaf (Vernonia amygdalina) is one of the potent plants as antidiabetic, antibacterial,
antifungal, analgesic and antioxidant. The aims of this study was to determine the wound healing
effect of ethanolic extract of african leaves gel and obtain an effective formula. It was an experimental
research. Injuries were made by cutting the back of mice’s skin with diameter ± 1 cm. Fourty eight
mice were divided into 8 groups, one group as control, EEDA 1%, EEDA 3% , EEDA 5%, EEDA 7%,
EEDA 9% , Bioplacenton as positif control and base gel group. The observation was done by
measured the diameter of wound visually. The mice declared cure and marked growth of new skin and
hair around the wound. At the end of the test performed histophatological test. This study concluded
the ethanol extract of Africa leaves have wound healing effect in mice and EEDA 9% have wound
healing effect at 15th daya.