Anemia is one of the health problems that adolescents often suffer, while in young women it has a big impact, among others, it can cause irregular menstruation which, if left unchecked, will have an impact on their reproductive health, as future mothers. The combination of guava juice and red spinach can increase the hemoglobin level of adolescent girls. The purpose of this study was to determine the difference in the effectiveness of the combination of red guava juice and red spinach with Fe tablets on increasing hemoglobin levels in female adolescents in the dormitory of the Midwifery department at Poltekkes Medan. This research is a quasi- experimental study examining a population consisting of 30 female adolescents, where 15 respondents were included in the combination group of red guava juice and red spinach, while 15 others were included in the Fe tablet group. Through research, the following results were obtained: the average hemoglobin level before consuming the combination of red guava juice and red spinach was 10.9400, after that it became 14.4133; the average hemoglobin level before consumption of Fe tablets was 11.1333 and after that it became 13.5800. It was found the effectiveness of consuming a combination of red guava juice and red spinach on increasing hemoglobin levels with a p-value of 0.000 <0.05, and it was also found that the effectiveness of consuming Fe tablets on increasing hemoglobin levels with a p-value of 0.000 <0.05. It was found that there was a difference in the effectiveness of consuming a combination of red guava juice and red spinach with consumption of Fe tablets on increasing hemoglobin levels, where the p-value was 0.024 <0.05. It is expected that health workers provide dissemination about the benefits of guava juice combined with red spinach to increase hemoglobin levels in female adolescents.