Microorganisms that cause disease stick to the hands through physical contact with the environment. The easiest and most appropriate way to clean them is by washing your hands with soap and clean water. If clean water is not available, use an alcohol-based hand sanitizer or contains an antibacterial known as a hand sanitizer which contains a synthetic antiseptic which is relatively expensive and whose use causes dry, cracked skin and even hypersensitivity. It is necessary to look for an antiseptic made from natural ingredients that is effective, relatively safe, easy to obtain, and more affordable, namely the kecombrang flower because it contains flavonoids, essential oils with an aromatic smell, and has traditionally been used to stop bleeding and eliminate body odor. Fresh kecombrang flowers as test material were crushed and dried at a temperature of around 60OC, until dry powder was obtained. Liquid gel formulation with concentrations of 5%, 10% and 15%. Evaluation of the preparations obtained includes organoleptic tests, preference tests, homogeneity, pH, spreadability, stability, irritation to volunteer skin. The results show that the 10% concentration preparation is the best, very preferred, stable at room temperature storage for 12 weeks, no irritation occurs, and the 15% concentration is the most effective, killing Staphylococcus aureus and Escherichia coli bacteria in a strong category so that kecombrang flower liquid gel can be used to clean hands from bacteria, its use is easy, practical, safe without using water