EVALUATION OF ANTIBIOTIC DOSE APPROPRIATENESS IN PATIENTS WITH CHRONIC RENAL FAILURE IN HAJI ADAM MALIK HOSPITAL MEDAN ON PERIOD JANUARY – JUNE 2014

Abstract

Antibiotic is a substance produced by microbes that can inhibit or eradicate other microbes. In
patients with chronic renal failure, the adjustment dose of antibiotic based on creatinine clearance. As
some antibiotics are mainly excreted through renal, therefore it is necesarry to adjust the dose. One
important indicator to reach therapy is the accuracy in giving dose to inhibit the progression of renal
disease and to maintain the patient’s life quality. The aim of this study was to evaluation of antibiotic
dose appropriateness in patients with chronic renal failure in Haji Adam Malik Hospital Medan on
period January – June 2014. The method of dose adjustment in patients with renal failure is based on
the drug clearance by Cockcroft-Gault equation. There are 82 medical records of patients with chronic
renal failure which fits the inclusion criteria and used as a sample. The result showed that the majority
of patients with chronic renal failure was at 39 – 48 years old (30,5%) and female (51.2%). Based on
the stage, the majority of patients with chronic renal failure was stage 5 (72%), followed by stage 4
(18.3%), stage 3 (8.5%) and stage 2 (1.2%). The most widely antibiotic which used by patients with
chronic renal failure was ceftriaxone (59.7%). The dose appropriateness of antibiotic was 93%. There
was no difference of dose in patients with chronic renal failure in Haji Adam Malik Hospital Medan
on period January – June 2014 based on characteristics of age, sex and stage chronic renal failure.
It can be concluded that the dose of antibiotic use in patients with chronic renal failure on
period Januay – June 2014 was appropriated, in accordance with standard treatment recommended by
Haji Adam Malik Hospital Medan.