tramadol ASSAY OF TRAMADOL WITH SEMI NONAQUEOS TITRATION IN CAPSUL DOSAGE

SEMI NONAQUEOS TITRATION IN CAPSUL DOSAGE

Abstract

ABSTRAC

Background : Analgesic drugs have the effect of eliminating or reducing pain without loss of consciousness. One of drugs used is tramadol HCl

Purpose : The purpose of this study was to determine the levels of tramadol HCl   accordance with the requirements of the pharmacopoeia Indonesia fourth edition 1995.

Research methods : Assay of tramadol HCl with semi nonaqueos titration used solvent mixture of ethanol and water with phenolphthalein indicator and titrate with NaOH cause pink discoloration.

Research results : The results showed that the semi nonaqueos titration method can be used and levels generic tramadol HCl PT. Indofarma (101,68% ± 1,37), tramadol HCl PT. Kimia Farma (103,10% ± 2,49) and branded drugs Tramal® (104,73% ± 2,55)  and Tradosik® (106,06% ±1,56).

Conclusions : Content of tramadol which has been checked to meet the requirements standard of  the Indonesian fourth edition pharmacopoeia  which is not less than 90% and not more than 110% of the amount listed on the label.

Keywords: Tramadol HCl, semi nonaqueos titration.